Synthesis, Anticancer and Antibacterial Activity of Mannose-based bis-1,2,3-Triazole Derivatives

In the current work, aromatic amines and alkyl halides have been converted to corresponding azides 2a‒d 4a-d by reaction with sodium nitrite azide respectively for halides. Then, dipropargyl ether derivative of D-mannose 8 has synthesized from diacetone mannose that obtained treatment (5) dry acetone in presence sulfuric acid. aldol condensation used prepare diol 7 diacetonide 6. The compound propargyl bromide alkaline media afforded 8. a parallel step, both dialkyne aliphatic coupled produce 1,2,3-triazole derivatives 9a‒d Cu(I) salts. All compounds characterized 1D 2D NMR spectra alongside HRMS data. antibacterial activity against gram-positive gram-negative tested. Moreover, anticancer also evaluated AMJ13 cell line.